Advanced Animal Disease Diagnosis and Management consortium

Introduction:

The North Eastern Region of India, owing to its unique geographical location sharing five international borders, bears a constant threat to India’s livestock of incursions of exotic, transboundary diseases through its porous border. It is needless to emphasize that the most scientific approach to effectively deal with such threats would be to strengthen regional infrastructure and capabilities in the direction of developing latest diagnostics and organizing rigorous surveillance for the highly contagious and ravaging diseases so as to have complete vigil on the disease situation of emerging and exotic infections and to build a formidable defense to guard the territories. The present project has been framed as an important step towards this direction.

The DBT Center in NE on Advanced Animal Disease Diagnosis and Services management is a tripartite concept. It involves and links three developed infrastructural facilities of the country which includes NE laboratories, three National Labs and eight Directorates of Animal Husbandry and Veterinary in NER. The project will operate for five years. All these Institutions will coordinate in mission of animal diseases monitoring (endemic, ubiquitous and transboundary animal diseases), development of sensitive disease diagnostic protocols and user friendly diagnostic kits, data base management and training to the regional and state level scientists and technical manpower, supplying diagnostic reagents.

There are a number of animal science institutes in the country carrying out R & D Research under the ICAR/SAU/CAU, DRDO as well as CSIR. The CSIR/DBT institutes do mainly basic research in Animal sciences where as ICAR institutes/SAU/CAU are focussing on applied aspects. The most desired aspect would be a fusion of the two, and a liaison between the two on diagnostic empowerment regarding transboundary animal diseases. A nodal facility in the North east to address the issue of providing rapid diagnostic service and competence in detection and identification of major pathogens would be developed using available expertise from the national institutes. This facility would address the issue of health services in context of the animal- human-environment continuum. Finally such a facility would help in development of core competence in the north eastern part of the country.

The broad roles of all partners at regional as well as national levels would be

Objectives:

Network Partners:


College of Veterinary Science, AAU, Khanapara

The lead center would coordinate with the other two core labs viz, Barapani and Selesih regarding progress and implementation of the project. The repository would be located at the lead center. The database regarding results and screening status would be maintained at the lead center. Budgetary powers would be however restricted to the center in question. National laboratory training programme would be coordinated by the lead center. The lead center would be responsible for compilation and report communication to the implementing agency.

The College of Veterinary Sciences, Khanapara would be involved in screening samples from the states of Assam, Arunachal and Sikkim. The Khanapara lab would collaborate with HSADL for work pertaining to diagnosis, testing and sampling for PRRS, Nipah, BVDV, WNV and Type A Influenza. The collaboration with VTCC would be on JEV, WNV, and Influenza A. The collaboration with PDADMAS would be in the areas of multi drug resistant bacteria, Brucella, Leptospira, Pasteurellosis, CSFV and other emerging diseases. Work on parasitological aspects and pathology would be carried out at the lead center with respect to samples send from the states under its jurisdiction and also in certain cases of referral nature from the Barapani and Mizoram labs. A disease status update would also be conveyed regularly to the respective state governments and sample results would also be communicated. The center would also analyze samples for viral etiologies from Mizoram center and also communicate the same to the center. A core disease database would be maintained at the center and periodic updates would be done by the three core labs under intimation to the lead center.

ICAR Research Complex for NEH Region, Barapani

The ICAR research complex would be involved in screening samples from the states of Meghalaya, Tripura and Nagaland. The ICAR Research complex Barapani would collaborate with HSADL for work pertaining to diagnosis, testing and sampling for PRRS, Nipah, BVDV, WNV and Type A Influenza. The collaboration with VTCC would be on JEV, WNV, Influenza A. The collaboration with PDADMAS would be in the areas of multi drug resistant bacteria, Brucella, Leptospira, Pasteurellosis, CSFV and other emerging diseases. A disease status update would also be conveyed regularly to the respective state governments and sample results would also be communicated. The center would also analyze samples for viral etiologies from Mizoram center and also communicate the same to the center. Regular networking would be maintained with the lead center at Khanapara.

  1. Monthly sample receipt details along with samples would be supplied to enrich the regional/National repository.
  2. Liaison with the lead center regarding validation of diagnostic protocols as per need.
  3. Information sharing and status update with regard to prevalence of diseases and help in building a digital database of the project.
  4. Coordination with lead center in organizing training programmes and carrying out sensitization workshops.

College of Veterinary Sciences, Selesih, Aizawl

The College of Veterinary Sciences, Aizawl would be involved in screening samples from the states of Mizoram and Manipur. The Aizawl lab would collaborate with HSADL for work pertaining to diagnosis, testing and sampling for PRRS, Nipah, BVDV, WNV and Type A Influenza. The collaboration with VTCC would be on JEV, WNV, and Influenza A. The collaboration with PDADMAS would be in the areas of multi drug resistant bacteria, Brucella, Leptospira, Pasteurellosis, CSFV and other emerging diseases. Work would be mainly done on bacteriology and specific aspects of multi drug resistant bacteria would be studied. PD ADMAS based protocols would be adopted and disseminated to the state directorates periodically. A disease status update would also be conveyed regularly to the respective state governments and sample results would also be communicated. The center would also dispatch samples to the Khanapara and Barapani labs for virological confirmations. Training would also be a major mandate of this center.

ICAR-National Research Centre on Pig, Rani, Guwahati

The NRC on pig, Rani Guwahati would help in establishing sampling from the point of view of porcine value chain. It would be imperative to assess the extent of sampling throughput in commercial stock of pigs. Furthermore diagnostic infrastructure for detection of common porcine diseases would be carried out at the NRC on pig.

ICAR-National Institute of High Security Animal Disease, Bhopal

Broad mandate

Different diagnostic protocols are to be developed:

ICAR-National Research Centre on Equines/Veterinary Type Culture Centre, Hissar

Broad mandate

Diseases to be taken up.

Influenza A (Equine and Swine), Japanese Encephalitis/West Nile fever, Trypanosomosis, Exotic diseases (need based), Other diseases as per contemporary Pest Risk Analysis base

Surveillance for diseases

ICAR-National Institute of Veterinary Epidemiology and Disease Informatics,Bengaluru

Broad mandate

  1. Livestock Disease Informatics – Epidemiology of endemic, emerging and TAD including Early warning system and Risk assessment.
  2. Technology Development – Development of Diagnostics
  3. Capacity Building – HRD through Training

A). Surveillance and Molecular analysis of MRSA, MR-CoNS, VRE; ESBL and Carbapenemase producing Gram-negative bacteria in farm animals and the animal handlers in NE India

B). Sero-epidemiological study of brucellosis in livestock in North East states of India using ELISA and Fluorescent Polarization Assay.

C). Epidemiological study of Classical swine fever (CSF), porcine reproductive and respiratory syndrome (PRRS) and porcine torqueteno (TTV) in pigs in North East (NE) region of India.

State Animal Husbandry Departments (Assam, Arunachal Pradesh , Sikkim, Meghalaya, Nagaland, Tripura, Manipur and Mizoram)

EXPECTED OUTCOME OF THE CENTER:

  1. State-of-the-art modern laboratories will be functioning in the NER by the time the project is completed.
  2. A critical mass of human resource (scientists, veterinarians, technicians etc) trained in issues and perspectives of eTADs will be available for the nation.
  3. Capacity for early (preferably pre-clinical) confirmatory diagnosis of eTADs will lead to timely reporting of the disease which will be helpful in early implementation of the disease control strategies/programmes.
  4. Technologies/Products in the form of a battery of diagnostic assays/kits, vaccines, repository of sera and clinical samples will be available after the completion of the project.
  5. A scientifically validated Disease Database will also be available at the end of the project, which will be helpful in keeping an eye on emerging and exotic animal diseases. This database will further be helpful in strategizing the disease control and eradication programmes and policies.
  6. New knowledge and information on disease, pathogens, epidemiologically valid data on various diseases, nucleotide and protein sequence data on many pathogens will also be the important outcome of the funding – the new information added in the world literature will enhance the prestige of the scientific community in particular and the country in general.
  7. Addition of the isolates arising out of DBT-assisted programme to VTCC repository will further strengthen the repositories existing at VTCC and NRCE which will be a national resource for posterity.
  8. The DBT funding will help in further strengthening of the existing repository facility which will be a national asset.
  9. Continuous surveillance of emerging transboundary diseases will help in keeping a vigil of disease scenario in the country vis-à-vis neighbouring countries and other countries which may be a risk country to us. The surveillance and monitoring will also give an idea about the microdata on livestock population and the dynamics of livestock husbandry and role the livestock diseases can play in food safety and security, nutritional security, animal welfare, human well-being, and national/global economy. The disease data compiled after continuous surveillance and monitoring will be useful in notifying the disease status and preparing the dossiers for seeking freedom from the disease. Besides, the data generated from the project will help in assessing the disease risk, if any. Due to international movements of men/material/animals, including vector population; there is could be a chance of introduction of the exotic disease(s) in the country and there is a need to be vigilant by bringing the country in “Preparedness State” for immediate diagnosis and identification of any new disease/pathogen incursion in the country.
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